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  • CESU
  • Initial training, continuing education
  • Presential
  • 50-60 hours over 2 weeks (February-June each year)

Pharmacometrics is a rapidly evolving and growing field. There is an urgent need of trained experts capable of developing and applying PBPK models with various purposes, such as R&D of new pharmaceuticals, inter-individual variability handling and assessment of toxicological risks. This course will give you the theoretical and technical knowledge to accurately develop, apply and evaluate PBPK models.

  • Objectives

    The objective of the course is for the attendees to master the concepts and the in silico tools for PBPK models. The concepts include pharmacokinetic ADME parameters, in vitro models, in vitro/in vivo extrapolation, chemical structure-properties relationships, model optimization, simulation, parameter-sensitivity analysis. The attendees will practice on Matlab Simbiology, Berkeley-Madonna, R, GastroPlus, PKSim and Simcyp during hands-ons.

  • Organization of the training

    The course will last over 2 weeks, either consecutive or separated by 1 or more weeks. The 50-60 hours of teaching will be divided in 50% theory and 50% hands-ons on usual mathematical and PBPK modeling softwares. The last day will be devoted to an evaluation of the acquired skills.

  • Further education

    The course is intended to post-graduate students or professionals having already attended the "Fundamentals for modeling and simulation in pharmacokinetics/pharmacodynamics " course. Validating both courses will lead to the delivery of the university diploma "Modeling and simulation: physiologically-based pharmacokinetic modelling for pharmacology and toxicology", which will certify an advanced level in population modeling, which is sought for various positions in the pharmaceutical industry and in regulatory drugs or toxicology agencies.

  • Admission conditions

    Previous validation of the course "Fundamentals for modeling and simulation in pharmacokinetics/pharmacodynamics" is a pre-requisite.

  • Partnership

    The course will be animated by diverse recognized experts of each subject, professionals from the academia (French and international) and from the industry (Pharma companies, CROs).

  • Other information

    The courses will be given in English.


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